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ICLUSIG (ponatinib) patient profiles*
Identifying patients with CP-CML who may be appropriate for ICLUSIG
ICLUSIG may help patients with distinct clinical features and TKI resistance
![Maddy with CP CML.](/hcp/sites/default/files/styles/image_block/public/2022-09/Maddy-CML-PP.png?itok=CEiwNcum)
Resistant CML
“My diagnosis at 33 years old upended my life. Now I’m trying to survive this chronic disease, with minimal disruption to my daily routine.”
Maddy | 35
Recently engaged entrepreneur
Diagnosis:
CP-CML
Mutations in BCR::ABL:
None
Comorbidities:
None
BCR::ABL1:
16%
Prior Course of Treatment:
dasatinib (18 months), bosutinib (6 months)
![Cynthia with CP CML.](/hcp/sites/default/files/styles/image_block/public/2022-09/Cynthia-CML-PP.jpg?itok=pSepaT6n)
Resistant CML
“As someone with a science background, I’m very involved in my CML treatment decisions. I always check each drug’s clinical track record to ensure I’m receiving an effective treatment that’s backed up by long-term data.”
Cynthia | 72
Retired mental health counselor with six grandkids
Diagnosis:
CP-CML
Mutations in BCR::ABL:
None
Comorbidities:
Diabetes (Controlled)
BCR::ABL1:
19%
Prior Course of Treatment:
nilotinib (33 months), dasatinib (15 months)
![Alan with CP CML with the T315i mutation.](/hcp/sites/default/files/styles/image_block/public/2022-09/Alan-CML-PP.jpg?itok=d3uFmFK3)
Mutation-positive CML
"According to my doctor, I just tested positive for a mutation in CML. I'm nervous to find out what this means for my treatment options."
Alan | 49
Chef and avid golfer
Diagnosis:
CP-CML
Mutations in BCR::ABL:
T315I
Comorbidities:
Hypertension (Controlled)
BCR::ABL1:
21%
Prior Course of Treatment:
imatinib (51 months)
*Hypothetical patient profiles
ICLUSIG demonstrated efficacy in CML
ICLUSIG shows efficacy in heavily pretreated, TK-resistant patients
BCR::ABL1IS=BCR::ABL1 international scale; CP=chronic phase; CP-CML=chronic phase chronic myeloid leukemia; CML=chronic myeloid leukemia; CV=cardiovascular; TKI=tyrosine kinase inhibitor.