Treating BCR::ABL1 Mutations, Including T315I
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Understanding BCR::ABL1 mutations, including T315I, and how they affect treatment
Why should you get tested for BCR::ABL1 mutations?
Sometimes, medications start to lose their effectiveness over time. If you see your BCR::ABL1 levels rise, this may be due to treatment resistance. One reason your treatment may become resistant is that over time, your chronic myeloid leukemia (CML) has developed a mutation. A mutation is a change in a gene. For CML, it is a change in the BCR::ABL1 protein. This may cause a particular treatment to stop working.
T315I is the most common BCR::ABL1 mutation. Your doctor should test your blood for the BCR::ABL1 protein, specifically the T315I mutation, and monitor your BCR::ABL1 levels every 3, 6, and 12 months when you're on treatment.
There are only a few CML treatments that have been specifically designed to treat people with a T315I mutation.
Your mutation status may change throughout your treatment journey. The presence of mutations plays an important role in your next treatment decision. Ask your doctor about mutation testing to ensure you are on the right track for your therapy.
How BCR::ABL1 mutations may affect your treatment journey
When your TKI treatments along with other genetic factors cause the T315I mutation, ask your doctor about ways to regain your treatment effectiveness. Your doctor may recommend that you change to a different TKI that works better against the mutation.
How ICLUSIG benefits adults with BCR::ABL1 mutations, including the T315I mutation
The goal of treating your CML is to reduce the levels of BCR::ABL1 and keep them low.
If your BCR::ABL1 levels rise, this may be due to treatment resistance caused by a mutation. The T315I mutation in particular is present in a significant number of patients who are resistant to therapy. ICLUSIG was the first TKI to be approved to treat people with the T315I mutation.