Treating BCR-ABL Mutations, Including T315I

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Understanding BCR-ABL mutations, including T315I, and how they affect treatment

Why and how to get tested for BCR-ABL mutations

Sometimes, medications start to lose their effectiveness over time. If you see your BCR-ABL levels rise, this may be due to treatment resistance. One reason your treatment may become resistant is that over time, your CML has developed a mutation. A mutation is a change in a gene. For CML, it is a change in the BCR-ABL protein. This may cause a particular treatment to stop working.

T315I is the most common BCR-ABL mutation. Your doctor should test your blood for the BCR-ABL protein, specifically the T315I mutation, and monitor your BCR-ABL levels every 3, 6, and 12 months when you're on treatment.

There are only a few CML treatments that have been specifically designed to treat people with a T315I mutation.

Your mutation status may change throughout your treatment journey. The presence of mutations plays an important role in your next treatment decision. Ask your doctor about mutation testing to ensure you are on the right track for your therapy.

How mutations may affect your treatment journey

When your TKI treatments along with other genetic factors cause the T315I mutation, ask your doctor about ways to regain your treatment effectiveness. Your doctor may recommend that you change to a different TKI that works better against the mutation.

How ICLUSIG benefits adults with mutations, including the T315I mutation

The goal of treating your CML is to reduce the levels of BCR-ABL and keep them low.

If your BCR-ABL levels rise, this may be due to treatment resistance caused by a mutation. The T315I mutation in particular is present in a significant number of patients who are resistant to therapy. ICLUSIG was the first TKI to be approved to treat people with the T315I mutation.

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